Natural history of coronary atherosclerosis

by C. Velican

Publisher: CRC Press in Boca Raton, Fla

Written in English
Cover of: Natural history of coronary atherosclerosis | C. Velican
Published: Pages: 426 Downloads: 573
Share This

Subjects:

  • Coronary heart disease -- Etiology.,
  • Coronary heart disease -- Pathophysiology.,
  • Coronary Arteriosclerosis.

Edition Notes

Includes bibliographies and index.

Statementauthors, Constantin Velican, Doina Velican.
ContributionsVelican, Doina.
Classifications
LC ClassificationsRC685.C6 V45 1989
The Physical Object
Pagination426 p. :
Number of Pages426
ID Numbers
Open LibraryOL2032446M
ISBN 100849369355
LC Control Number88008128

Therapeutic modulation of the natural history of coronary atherosclerosis: lessons learned from serial imaging studies Despite advances in risk prediction, preventive and therapeutic strategies, atherosclerotic cardiovascular disease remains a major public health challenge worldwide, carrying considerable morbidity, mortality and health.   Treatment for atherosclerosis is often critical when it affects the arteries leading to your heart, a condition known as coronary artery disease (CAD). Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography: Results of the PARADIGM Study. Author(s): Kim, Ung.   This is because atherosclerosis is the underlying medical problem in most patients with any of the following illnesses: Coronary artery disease — In this chronic (long-lasting) disease, atherosclerosis narrows the coronary arteries, the arteries that supply blood to the heart muscle. This can lead to the chest pain called angina.

Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am . Atherosclerosis is a disease in which the wall of the artery develops abnormalities, called lesions. These lesions may lead to narrowing due to the buildup of atheromatous plaque. Initially, there are generally no symptoms. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are affected. We have detected that you are using an Ad Blocker. PracticeUpdate is free to end users but we rely on advertising to fund our site. Please consider supporting PracticeUpdate by whitelisting us in . Background and Purpose—Knowledge of the natural history of stenoses due to intracranial atherosclerosis may be useful for evaluating possible treatments such as angioplasty.. Methods—We retrospectively reviewed records over a 7-year period to identify patients with intracranial atherosclerotic stenoses and serial tative measurements of stenoses were made in a blinded.

Atherosclerosis can create life-threatening blockages in the arteries of your heart, without you ever feeling a thing. Learn more from WebMD about coronary artery disease. fewer coronary events [24–27]. Hence atherosclerosis is a primary disease of lipids, not inflamma-tion, so the answer to query #8: Fancy. Fact of Fancy #9: The concept that inflammation plays a role in the progression of atherosclerosis is a new idea. Answer #9: Fancy. Discussion: Recent research work has identified molecular and cel-. The natural history of aortic atherosclerosis: a systematic histopathological evaluation of the peri-renal region. Atherosclerosis ; Davies MJ, Woolf N, Rowles PM, Pepper J. Morphology of the endothelium over atherosclerotic plaques in human coronary arteries.

Natural history of coronary atherosclerosis by C. Velican Download PDF EPUB FB2

We therefore performed a prospective, multicenter study of the natural history of coronary atherosclerosis, using multimodality intravascular imaging Natural history of coronary atherosclerosis book identify the clinical and lesion-related Cited by: july natural history of coronary atherosclerosis 73 table 6-mean atherosclerotic indices of right coronary left anterior descending coronary and the left circumflex coronary arteries in each decade age group (years) below 10 right coronary ±* () o± ().

The natural history of coronary atherosclerosis has been reconstructed from data gathered from consecutive medicolegal necropsies. Coronary atherosclerosis in men commences in the second decade in the form of fatty spots which are most frequent in the anterior descending branch of the left coronary by: 5.

A Prospective Natural History Study of Coronary Atherosclerosis Gregg W. Stone MD, Akiko Maehara MD, Alexandra J. Lansky MD, Bernard de Bruyne MD, Ecaterina Cristea MD. Natural history of coronary atherosclerosis did contemporary medical therapy change the course. Ain, David L.; Jang, Ik-Kyung.

Author Information. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Natural history of coronary atherosclerosis / authors, Constantin Velican, Doina Velican CRC Press Boca Raton, Fla Wikipedia Citation Please see Wikipedia's template documentation for further citation fields that may be required.

Fingerprint Dive into the research topics of 'In-vivo assessment of the natural history of coronary atherosclerosis: Vascular remodeling and endothelial shear stress determine the complexity of atherosclerotic disease progression'.

Together they form a unique fingerprint. HOLMAN RL, McGILL HC, Jr, STRONG JP, GEER JC. The natural history of atherosclerosis: the early aortic lesions as seen in New Orleans in the middle of the of the 20th century.

Am J Pathol. Mar-Apr; 34 Natural history of coronary atherosclerosis book [PMC free article] DAWBER TR, MOORE FE, MANN GV. Coronary heart disease in the Framingham study. In order to complete the fragmentary knowledge of the natural history of atherosclerosis, the authors examined the coronary arteries of captive and wild vertebrates living in freedom, as well as the aortas of of by: The natural history of coronary atherosclerosis has been reconstructed from data gathered from consecutive medicolegal necropsies.

Coronary atherosclerosis in men commences in the second decade in the form of fatty spots which are most frequent in the anterior descending branch of the left coronary artery.

The earliest evidence of atherosclerosis in women was seen in the third by: 5. In-vivo assessment of the natural history of coronary atherosclerosis: Vascular remodeling and endothelial shear stress determine the complexity of atherosclerotic disease progression.

The extent of stress-induced myocardial ischemia is an important determinant of outcome in patients with stable coronary artery disease. The natural history of atherosclerotic lesions was previously investigated with intracoronary imaging, mainly focusing on plaque composition without accounting for the potential impact of mechanical stress exerted on the plaque itself by intracoronary.

Objectives This study aimed to determine the rate and extent of plaque progression (PP), changes in plaque features, and clinical predictors of PP in patients with diabetes mellitus (DM).

Background The natural history of coronary PP in patients with DM is not well established. Methods A total of 1, patients (age ± years; % men; median scan interval years) who underwent. A prospective natural-history study of coronary atherosclerosis N Engl J Med.

Jan 20;(3) doi: /NEJMoa Authors Gregg W Stone 1. The natural history of coronary artery stenosis has to be studied by comparison of coronary angiograms of the same patient taken at different times. Unfortunately, although thousands of coronary angiograms are performed each year, only a limited number of repeated studies is available, particularly in patients who are medically treated over an.

OBJECTIVES: This study sought to analyze the natural history of coronary atherosclerosis by multislice computed tomography (MSCT) and assess the serial changes in coronary plaque burden, lumen dimensions, and arterial remodeling.

BACKGROUND: MSCT can comprehensively assess coronary atherosclerosis by combining lumen and plaque size parameters. A Prospective Natural History Study of Coronary Atherosclerosis Using Fractional Flow Reserve Emanuele Barbato, Gabor G. Toth, Nils P. Johnson, Nico H.J. Pijls, William F. Fearon, Pim A.L.

Tonino, Nick Curzen, Zsolt Piroth, Gilles Rioufol, Peter Jüni and Bernard De Bruyne. Natural History of Diabetic Coronary Atherosclerosis by Quantitative Measurement of Serial Coronary Computed Tomographic Angiography: Results of the PARADIGM Study (Progression of Atherosclerotic Plaque Determined by Computed Tomographic Angiography Imaging).

JACC Cardiovasc Imaging ;May [Epub ahead of print]. Summary By. natural history of coronary atherosclerosis from a coronary hemodynamic perspective. METHODS PATIENTS. The study design and the results of the FAME-2 trial have been previously reported (7). In short, the FAME-2 trial randomized consecutive patients with stable angina and angiographically.

Objectives This study sought to analyze the natural history of coronary atherosclerosis by multislice computed tomography (MSCT) and assess the serial changes in coronary plaque burden, lumen dimensions, and arterial remodeling. Background MSCT can comprehensively assess coronary atherosclerosis by combining lumen and plaque size parameters.

Methods Thirty-two patients with acute coronary. Advances in the Diagnosis of Coronary Atherosclerosis. Edited by: Suna F. Kiraç. ISBNPDF ISBNPublished Proposed timeline of coronary atherosclerosis and contribution of microRNA (miR) transcoronary gradients (TCGs) at each step. Interestingly, at most stages, miR, miR, and mi appear to be in abundance throughout the disease process, while very few miRs have reduced gradients (or are ‘retained’ in the circulation).

A prospective natural-history study of coronary atherosclerosis. By Gregg Stone, Akiko Maehara, Alexandra Lansky, Bernard Bruyne, Ecaterina Cristea, Gary Mintz, Roxana Mehran, John McPherson, Naim Farhat, Steven Marso, Helen Parise, Barry Templin, Roseann White, Zhaoyong Zhang and.

porting the role of low ESS in the natural history of coronary atherosclerosis and vascular remodeling and indi-cate likely mechanisms concerning the different natural history trajectories of individual coronary lesions. Ath-erosclerotic plaques associated with excessive expansive remodeling evolve to high-risk plaques, because low.

Yabe Y. () Natural History of Coronary Artery Disease: The Effects of Ca 2+ Channel Blockade and Antiplatelet Agent on Progression or Regression of Coronary Atherosclerosis. In: Kelly D.T. (eds) Adalat® in the Asian Pacific Region.

Janu —In the New England Journal of Medicine, Gregg W. Stone, MD, et al have published findings from PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree), a prospective natural history study of coronary atherosclerosis (;).

According to the PROSPECT investigators, atherosclerotic plaques that lead to acute coronary. understand the natural history of this disease, and its responsiveness to different treatments.

This has been Review Article Therapeutic modulation of the natural history of coronary atherosclerosis: lessons learned from serial imaging studies Jordan Andrews 1, Rishi Puri2,3, Yu Kataoka4, Stephen J.

Nicholls, Peter J. Psaltis. In book: Biomechanics of Coronary Atherosclerotic Plaque, pp Further understanding of the role of ESS in atherosclerosis in coronary bifurcations, utilizing advanced imaging and. View This Abstract Online; A prospective natural-history study of coronary atherosclerosis.

N Engl J Med. ; (3) (ISSN: ). Stone GW; Maehara A; Lansky AJ; de Bruyne B; Cristea E; Mintz GS; Mehran R; McPherson J; Farhat N; Marso SP; Parise H.

To the Editor: I would like to comment on two issues related to the article by Stone et al. on the natural history of coronary atherosclerosis (Jan. 20 issue).1 First, most of the patients were dis. Coronary Atherosclerosis Blood vessels are very sensitive structures which respond to hemodynamic changes.

Thus. endothelial nuclear shape and orientation e.g., elongated, flow-direction oriented nuclei in segments with stable flow; round, less ordered nuclei in segments with unsteady, turbulent flow and possibly the density of endothelial nuclei depend upon stresses secondary to flow dynamics.Imaging of adverse coronary plaque features has advanced greatly over the past decade and improved our understanding of the highly complex and dynamic nature of coronary atherosclerosis.

Moreover, adverse non-invasive plaque imaging and assessment of the adverse coronary plaque burden is an exciting novel approach for identifying the vulnerable. Stone GW, Maehara A, Lansky AJ, et al, for the PROSPECT Investigators. A prospective natural-history study of coronary atherosclerosis.

N Engl J Med. Jan (3) Stiles S. ESC refreshes guidelines for stable CAD, CVD with .